Ptolus teems with various factions and groups with agendas and secret goals. In brief, these include (but are not limited to):
- Balacazar Crime Family
- Brotherhood of Redemption
- The Conciliators
- Delver’s Guild
- Dreaming Apothecary
- The Fallen
- Fate Weavers
- The Forsaken
- Healers of the Sacred Heat
- Inverted Pyramid
- Keepers of the Veil
- Killraven Crime League
- Knights of the Golden Cross
- Knights of the Pale
- Longfingers Guild
- The Malkuth
- Order of the Fist
- Pale Dogs
- The Shuul
- The Sorn
- Sisterhood of Silence
- The Vai
- Viridian Lords
